INTRODUCTION

PASILOW 50 contains Cyclosporin which belongs to the group of medicines called immunosuppressive agents. Immunosuppressive agents are drugs that suppress or reduce the strength of the body’s immune system. It is used to prevent graft rejection in patients who have had organ transplants, bone marrow, and stem cell transplants.

It can also be used to treat various autoimmune diseases like severe rheumatoid arthritis, nephrotic syndrome (kidney disease), eye problems (endogenous uveitis, including Bechet's uveitis), and skin diseases (atopic dermatitis, or eczema and psoriasis). Cyclosporin blocks the development of cells that attack the affected transplanted tissue and suppress abnormal immune function thus preventing the rejection of transplanted organs.

Limit your exposure to sunlight and UV light by wearing protective clothing and by applying sunscreen to prevent skin cancer. Avoid the consumption of alcohol or grapefruit juice while taking this medicine. This medicine should not be given to children for any non-transplant disease, except for nephrotic syndrome. Do not take this medicine if you have any uncontrollable infection or any type of cancer. Consult your doctor for advice.

USES OF PASILOW 50

• Prevents the rejection of transplanted organs
• Treats severe rheumatoid arthritis
• Treats eye problems such as endogenous uveitis, including Bechet's uveitis

HOW PASILOW 50 WORKS

Cyclosporin works by inhibiting the production of various cytokines involved in the regulation of T-cell activation. These effects of cyclosporine on T cells and on connective tissue cells can produce a range of cytokines. These in turn promote antibody (Ab) secreting plasma cells which finally bind and inactivate the antigen.

DIRECTIONS FOR USE

Take this medicine as directed by your physician. Your doctor will decide the correct dose for you depending upon your condition. Avoid drinking grapefruit juice while taking this medicine.

SIDE EFFECTS OF PASILOW 50

• Fever or sore throat
• Signs of brain infection (e.g. changes in sight, loss of coordination, memory loss, difficulty in speaking, muscle weakness)
• Feeling agitated, sleeplessness
• Problems in urination
• Nausea, vomiting, abdominal pain, constipation, diarrhea
• Feeling numb or tingling
• Numbness or tingling in fingers and toes
• Swelling of face, stomach, hands, and/or feet
• Breast enlargement in men

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after a meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation:

Eat fiber rich foods like fresh fruit, vegetables and cereals. Drink plenty of water Exercise more regularly.

Diarrhea:

Drink lots of fluids to avoid dehydration. Avoid taking any medicines for Diarrhoea without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and more frequent meals. Keeping a heating pad on your stomach may also help. If still pain persists, speak to your doctor.

PREGNANCY

PASILOW 50 should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

PASILOW 50 should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Avoid driving or operating any machines, if your ability is affected by this medicine.