INTRODUCTION

BARINAT 2 contains Baricitinib which belongs to a group of medicines called Janus kinase inhibitors, which reduces inflammation. It is indicated to treat moderate to severe rheumatoid arthritis and atopic dermatitis (atopic eczema). Rheumatoid arthritis is an inflammatory disease of the joints. This medicine can also be used alone or together with some other medicines.

Baricitinib is a selective and reversible inhibitor of Janus kinase (JAK)1 and JAK2, which inhibits Janus kinase (JAK) enzymes, which are intracellular enzymes involved in stimulating hematopoiesis and immune cell function through a signaling pathway. JAKs activate signal transducers and activators of transcription (STATs), which regulate gene expression and intracellular activity.

Always take BARINAT 2 exactly as directed by your doctor. Tell your doctor if you have liver, kidney, or heart problems, are pregnant, or breastfeeding. This medicine is not recommended for use in children and adolescents below 18 years of age. The common side effects are headache, nausea, vomiting, cough, and infections.

USES OF BARINAT 2

Treats rheumatoid arthritis and atopic dermatitis (atopic eczema)

HOW BARINAT 2 WORKS

For rheumatoid arthritis, BARINAT 2 works by reducing the activity of an enzyme called Janus kinase, which is involved in inflammation. By reducing the activity of this enzyme, it helps to reduce pain, stiffness, swelling in your joints, and tiredness and helps to slow down the damage to the bone and cartilage in the joints.

For atopic dermatitis, BARINAT 2 works by reducing the activity of the Janus kinase enzyme and helps to improve the condition of the skin and reduce itching. It also helps to improve your sleep disturbance (due to itch) and overall quality of life.

DIRECTIONS FOR USE

Always take BARINAT 2 exactly as your doctor has told you. Swallow this medicine with a glass of water and do not crush or chew.

SIDE EFFECTS OF BARINAT 2

SERIOUS

• Painful skin rash with blisters and fever
• Chest tightness, wheezing
• Dizziness or light-headedness
• Swelling of the lips, tongue, or throat
• Hives (itching or skin rash)
• Abdominal pain accompanied by fever, nausea, and vomiting

COMMON

• Throat and nose infections
• High levels of blood fat
• Cold sores
• Infection causing a sick stomach or diarrhea
• Urinary infection
• Pneumonia
• The high number of platelets
• Headache
• Nausea
• Stomach pain
• High levels of liver enzymes
• Rash
• Acne
• Increase in enzymes

FAQs

Q1 Can I take Barinat 1 Tablet if I have liver problems? Inform your doctor if you have liver problems, before starting Barinat 1 Tablet. This is done because in some cases Barinat 1 Tablet may cause an increase in liver enzymes. Therefore, your liver function needs to be investigated before starting Barinat 1 Tablet. Although, Barinat 1 Tablet can be given to patients with mild to moderate liver function impairment, but should not be prescribed to patients with severe liver impairment.

Q2 Can Barinat 1 Tablet cause cancer? Barinat 1 Tablet may increase the chances of developing the risk of certain cancers (lymphoma and other cancers including skin cancers) by affecting the working of the immune system. Hence, inform your doctor if you ever had or have any type of cancer.

Q3 Do I need to get any investigations done before starting Barinat 1 Tablet? You may need to get your blood tests done before you start Barinat 1 Tablet or while you are taking it. Blood tests are done in order to check if you have a low red blood cell count (anemia), low white blood cell count (neutropenia or lymphopenia), high blood fat (cholesterol) or high levels of liver enzymes. It also helps to ensure that treatment with Barinat 1 Tablet is not causing problems. In addition to this, your doctor may advise you to get tested for tuberculosis before starting Barinat 1 Tablet, as using Barinat 1 Tablet may make an existing infection worse.